OvaCure is supporting UN Sustainable Development Goals: #3 #5 #17

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OvaCure is proud to announce our official support of the UN Sustainability Goals (SDG):

Goal 3: Ensure healthy lives and promote well-being for all at all ages

Ensuring healthy lives and promoting the well-being for all at all ages is essential to sustainable development. Significant strides have been made in increasing life expectancy and reducing some of the common killers associated with child and maternal mortality. Major progress has been made on increasing access to clean water and sanitation, reducing malaria, tuberculosis, polio and the spread of HIV/AIDS. However, many more efforts are needed to fully eradicate a wide range of diseases and address many different persistent and emerging health issues.

Each of OvaCure's projects have maximum potential for the development of curative treatments for ovarian cancer patients. OvaCure's first five projects are currently underway, with the flagship project, T-cell Infusion, being among the world's first trials to treat ovarian cancer patients with adoptive T-cell therapy (ACT). Through these projects OvaCure supports the UN’s target 3.4.1 of working towards decreasing the mortality rate attributed to cardiovascular disease, cancer, diabetes or chronic respiratory disease.

Goal 5: Achieve gender equality and empower all women and girls

While the world has achieved progress towards gender equality and women’s empowerment under the Millennium Development Goals (including equal access to primary education between girls and boys), women and girls continue to suffer discrimination and violence in every part of the world. Gender equality is not only a fundamental human right, but a necessary foundation for a peaceful, prosperous and sustainable world.

Providing women and girls with equal access to education, health care, decent work, and representation in political and economic decision-making processes will fuel sustainable economies and benefit societies and humanity at large.

OvaCure has aligned employment and leadership positions with the European Equal Treatment Directive 2006/54/EC. Currently, 8 out of 10 of OvaCure's Strategic Advisory Board members are women and 3 out of 6 of the Scientific and Clinical Advisory Board Members are women. Moreover, 3 out of 5 of OvaCure’s Active Projects are led by female principal investigators. This approach supports the UN target 5.5.2. of enhancing the proportion of women in managerial positions.

Goal 17: Revitalize the global partnership for sustainable development

A successful sustainable development agenda requires partnerships between governments, the private sector and civil society. These inclusive partnerships built upon principles and values, a shared vision, and shared goals that place people and the planet at the centre, are needed at the global, regional, national and local level.

Urgent action is needed to mobilize, redirect and unlock the transformative power of trillions of dollars of private resources to deliver on sustainable development objectives. Long-term investments, including foreign direct investment, are needed in critical sectors, especially in developing countries. These include sustainable energy, infrastructure and transport, as well as information and communications technologies. The public sector will need to set a clear direction. Review and monitoring frameworks, regulations and incentive structures that enable such investments must be retooled to attract investments and reinforce sustainable development. National oversight mechanisms such as supreme audit institutions and oversight functions by legislatures should be strengthened.

OvaCure has to-date, catalysed partnerships between Denmark, the United Kingdom, USA, Switzerland, Canada, Germany, France and the Netherlands. Hence, the OvaCure model supports the SDG target no. 17.16 of enhancing global partnerships for sustainable development.

Join our movement and become a member of OvaCure today by emailing mail@ovacure.org!

2 out of 3 approved anticancer drugs in the EU do not improve survival...

Global annual spending on cancer drugs has hit $100bn for the first time in history. But are these new and approved drugs providing survival benefits for patients? 

Global annual spending on cancer drugs has hit $100bn for the first time in history. But are these new and approved drugs providing survival benefits for patients? 

From 2009 to 2013, the EMA approved the use of 48 cancer drugs for 68 indications. The majority of these approved cancer drugs entered the market without clear evidence that they improved survival or quality of life for patients. Huseyin Naci, assistant professor of health policy at the London School of Economics has published evidence relating to a retrospective cohort study of drug approvals and their true benefits to patients and society. OvaCure accelerates clinical trial projects that have the potential to cure by increasing both overall survival and quality of life for patients. OvaCure believes that the best clinical outcomes will be achieved with personalised care. It is our hope that these endpoints will be prioritised by global regulatory agents, academia and industry when considering new clinical trial design and drug development.

Progress on many fronts- Targeting tumours with the newest technologies on offer

There is a lot more for immunotherapy to do in future cancer care.... The Economist has just released the Technology Quarterly which has provided a detailed insight into the current state-of-the-art in cancer care.  IMMUNOTHERAPY has been featured for its huge promise, both as an addition to established therapies and as a foundation for future ones. The importance of genetic screening of patient's tumours has also been highlighted. OvaCure believes that the cure to ovarian cancer lies in the tumour itself. We stand by these new cutting-edge technologies, which will uncover the secrets of the tumour, leading to curative treatment options for patients.  

There is a lot more for immunotherapy to do in future cancer care....

The Economist has just released the Technology Quarterly which has provided a detailed insight into the current state-of-the-art in cancer care. 

IMMUNOTHERAPY has been featured for its huge promise, both as an addition to established therapies and as a foundation for future ones. The importance of genetic screening of patient's tumours has also been highlighted. OvaCure believes that the cure to ovarian cancer lies in the tumour itself. We stand by these new cutting-edge technologies, which will uncover the secrets of the tumour, leading to curative treatment options for patients.

 

The OvaCure Foundation is now a 501(c)3 non-profit, tax-exempt charity in the USA!

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To change the game of ovarian cancer research - we have to go global!

OvaCure is pleased to announce our new non-profit US organisation status as a 501(c)3 tax exempt charity based on a letter of confirmation from the US Internal Revenue Service dated 18th July 2017. The OvaCure Foundation will function as our new US entity which will bridge our work across the pond. This status will help us accomplish our goals by engaging in new partnership building and US-based fundraising.

All US donations to the OvaCure Foundation are tax deductible and are 100% directed to our breakthrough, in-patient, clinical trial projects.
 

ASCO 2017 - Highlights!

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OvaCure attended ASCO for the first time this year in Chicago. It was a colossal event featuring the "rockstars" of oncology and great insights into new developments for ovarian cancer. Here are  our noted key highlights...

Combinations in Immuno-Oncology are all the hype

“As single agents, we have not broken the tolerance of the ovarian cancer yet – therefore combination is the name of the game” - Professor Samir Khleif stated in the Educational Session on Immunotherapy for Gynecologic Cancers that combinations are the key to overcome resistance by the tumour microenvironment. We will be seeing more clinical trials rolling out to test PARPi + combinations for maximum impact in the ovarian cancer patient population.

The mechanisms of action of surgery is removing all the tumour”

Professor Andreas Du Bois provided excellent insight into his promising DESKTOP III trial which offers surgery for recurrent ovarian cancer patients. This approach showed a clear survival advantage for the patients treated with this surgical approach and no toxicities or adverse effects.

New space for clinical exploration in Gyneacological Cancers

Lots of great energy around the Gynecologic Cancer poster session where 3 of OvaCure’s principle investigators Dr. Mansoor Mirza, Prof. Jonathan Ledermann and Prof. Charlie Gourley presented their findings to large crowds surrounding their posters.

CAR-T for all cancers is the goal

Professor Carl June gave a great talk about the universality of CAR-T therapy and how these “living drugs” are set to take Immuno-Oncology to the next level. Prof. June also received ASCO’s Highest Scientific Honor. The award goes to an oncologist who has made outstanding contributions to cancer research, diagnosis, and treatment. OvaCure is so proud to support the technology enabled by Prof. June and his research team at the University of Pennsylvania.

Biggest breakthrough in ovarian cancer treatment over the last Decade...

“With very few effective treatment options for ovarian cancer, an approach that develops new ways of targeting ovarian cancer cells more effectively, and with fewer side effects, is to be welcomed.” - Annwen Jones, chief executive of the charity Target Ovarian Cancer

“With very few effective treatment options for ovarian cancer, an approach that develops new ways of targeting ovarian cancer cells more effectively, and with fewer side effects, is to be welcomed.” - Annwen Jones, chief executive of the charity Target Ovarian Cancer

The drug known as ONX-0801 was recently tested in a trial run by the Institute of Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust in London.

This new therapy was tested in 15 women with advanced ovarian cancer and significantly shrank tumours in seven of the 15 ovarian cancer patients.

This new therapy attacks ovarian cancer by mimicking folic acid to enter the cancer cells. The drug then kills these cells by blocking a molecule called thymidylate synthase, thereby causing irreparable DNA damage.  

Ovarian cancer cells have an abnormally large number of receptors for folic acid, called alpha folate receptors. This means these cancer cells respond particularly well to the treatment. As the therapy is so specifically targeted at ovarian cancer cells, it leaves healthy cells alone. This means it does not have the side-effects, such as infections, diarrhoea, nerve damage and hair loss, often seen with chemotherapy.

OvaCure søger en studentermedhjælper til kommunikation og social media

Vil du være en del af en innovativ start-up, der ændre måden at kurere cancer på?

Brænder du for at være en del af en innovativ virksomhed, hvor der er højt til loftet og masser af udfordringer, så er du måske vores nye kommunikation og social media medarbejder, der vil være med til at gøre en forskel for kvinder med ovariecancer (æggestokkekræft) verden over.

Deadline 1. juli 2017.

OvaCure Live at the NSGO Nordic Hotspot for Rare Tumours in Gynaecological Cancers

OvaCure is excited to participate in the NSGO Annual Meeting in Helsinki, Finland today. With more than 70 international gyno-oncological experts in one room, we have a front seat to new knowledge exchange and innovation in ovarian cancer clinical research.

OvaCure is a proud collaboration partner with the Nordic Society of Gynaecological Oncology - we share successes which bring us closer to the cure for women with ovarian cancer.

Innovation in Standard of Care: PARP Inhibitors Approved for All Patients

On the 27th of March 2017, Tesaro’s PARP inhibitor named Zejula received FDA regulatory approval for the treatment of all recurrent epithelial ovarian cancer patients - irrespective of their BRCA 1/2 status. This is a major contribution to the current treatment regimen for these patients, who previously had less than a 30% chance of qualifying for treatment with this life-prolonging drug.

 

This paradigm shift in care was initiated by the results generated from the 553-patient NOVA study led by OvaCure’s collaborating principal investigator, Dr. Mansoor Raza Mirza. The trial revealed that all patients experienced significant clinical benefit from treatment with PARP inhibitors. Progression-free survival for patients treated with Zejula was up to 21 months. While those treated with a placebo, experienced a maximum of 5.5 months without progression of the disease.

This approval provides future relapsed patients with hope of better management of their disease, improved quality of life and a step closer to the cure. European approval of the use of Zejula for all epithelial ovarian cancer patients is currently under review.

OvaCure is proud to collaborate with Principal Investigator of this trial, Dr. Mansoor Raza Mirza in our Tumour-Match Project. 

ESMO Guidelines on Ovarian Cancer Care by Professor Jonathan Ledermann

A comprehensive review of the options available for the treatment of recurrent disease and discuss how different agents are selected, combined and offered in a rationale sequence in the context of multidisciplinary care. Published work between 1990 and 2013 and meeting abstracts are related to the use of chemotherapy and surgery in patients with recurrent ovarian cancer.

Professor Charlie Gourley on Advances in Ovarian Cancer Maintenance Therapy

Charlie Gourley, PhD, MBChB, chair and honorary consultant in Medical Oncology at Edinburgh Cancer Research Centre in the United Kingdom, discuses olaparib (Lynparza), which was recently investigated in a phase II Study 19 trial versus placebo as a maintenance therapy for patients with relapsed platinum-sensitive serous ovarian cancer.

The drug really works, says Gourley. The study was designed to look at progression-free survival (PFS), and, unequivocally, it clearly showed that this drug improved PFS, he says.  
 

Professor Inge Marie Svane is breaking new ground with Immunotherapy

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20 years ago, as a medical intern, Inge Marie Svane never would have guessed that she would be apart of the scientific breakthroughs which are today improving survival rates for cancer patients. Immunotherapy has been proclaimed to be the key to treat patients with a various cancer forms. Professor Svane is currently principal investigator for several clinical trials applying cellular-based immunotherapy to patients with metastatic melanoma, renal cell and ovarian cancers - offering the most promising hope for patients with advanced stage disease.

OvaCure's Dr. Mansoor Raza Mirza improving survival and shifting paradigms for ovarian cancer patients

The ASCO Post, 8th October 2016.

Mansoor Raza Mirza, MD,  Chief Oncologist of Rigshospitalet, Copenhagen University Hospital, impresses the crowd at ESMO 2016, Denmark with his phase III study findings on maintenance therapy with niraparib vs placebo in patients with platinum-sensitive recurrent ovarian cancer. 

Immunotherapeutic approaches to ovarian cancer treatment

By Late Holbrook Kohrt et. al. (2015.03.24)
Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA

OvaCure's co-founder, Late Associate Professor Holbrook Kohrt

OvaCure's co-founder, Late Associate Professor Holbrook Kohrt

Despite advances in combinatorial chemotherapy regimens and the advent of intraperitoneal chemotherapy administration, current therapeutic options for ovarian cancer patients are inadequate. Immunotherapy offers a novel and promising therapeutic strategy for treating ovarian tumors. Following the demonstration of the immunogenicity of ovarian tumors, multiple immunotherapeutic modalities have been developed. 

Antibody-based therapies, immune checkpoint blockade, cancer vaccines, and chimeric antigen receptor-modified T cells have demonstrated preclinical success and entered clinical testing. In this review, we discuss these promising immunotherapeutic approaches and emphasize the importance of combinatorial treatment strategies and biomarker discovery.

T-cell therapy offers lasting cure prospects, scientists say

OvaCure supports advances in immunotherapy approaches. It has shown great results in some cancer forms and OvaCure scientist are now applying T-cell therapy treatments in ovarian cancer patients - for the first time in the world.

Immunotherapy approaches are currently being tested in the clinical phases of several trials, yet there is great hope in its potential to cure cancer patients.

"A revolutionary cancer therapy that uses the body’s own immune cells to attack metastatic tumours that have spread is being hailed as a “paradigm shift” in treatment of the disease."